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☆ After weight loss, Alzheimer's may be next frontier for drugs like Ozempic
▼ + stars: | 2023-05-08 | by ( Natalie Grover | ) www.reuters.com time to read: +6 min

LONDON, May 8 (Reuters) - Diabetes drugs that also promote weight loss such as Novo Nordisk’s (NOVOb.CO) Ozempic, becoming a darling of celebrities and investors, are being studied to tackle some of the most difficult-to-treat brain disorders, including Alzheimer’s disease. Those successes followed decades of futility that had left many questioning the validity of the amyloid theory behind most experimental Alzheimer's drugs. She said she has since been approached by pharmaceutical companies at an increasing pace, and is currently running an Alzheimer’s trial evaluating intranasal insulin in combination with another diabetes drug. Four companies with GLP-1 drugs, including two larger drugmakers, say they are watching for results of trials testing Novo's drug in Alzheimer's. Dementia affects more than 55 million people globally and the market for Alzheimer’s drugs is expected to grow to $9.4 billion by 2028 and for Parkinson’s to $6.6 billion, according to pharmaceutical data provider Citeline.

☆ This 28-year-old ignored warnings about job-hopping and doubled her salary to $186K in 5 years
▼ + stars: | 2023-04-21 | by ( Jennifer Liu | In Jljenniferliu | ) www.cnbc.com time to read: +5 min

In 2019, she got a promotion to a product development role and a salary bump to $89,000. Product manager: $130,000By 2020, El-Amin began talking to former college classmates about moving to a new company. She spoke with a fellow alum who worked at Mastercard, who ended up referring her to a product manager job. Technical product manager: $186,000 plus a $29,000 signing bonusBy May 2021, El-Amin was looking to change course again. "I was probably a little too overly confident that I could just easily land another role as a product manager."

☆ As weight-loss drugs hit the U.S. market, doctors debate how to use them
▼ + stars: | 2023-03-30 | by ( Patrick Wingrove | ) www.reuters.com time to read: +6 min

[1/2] The American Medical Association logo is seen at their office in Washington, D.C., U.S., August 30, 2020. REUTERS/Andrew Kelly/March 30 (Reuters) - As powerful new obesity drugs enter the U.S. market, medical associations are keen to advise their members on how to best use them for patients. "These new compounds are game changers, there's no doubt about it," said Anthony Comuzzie, chief executive of The Obesity Society. The group last provided obesity treatment guidelines in 2013 alongside the American Heart Association and American College of Cardiology. OBESITY AS A DISEASEThe American Medical Association, the nation’s largest medical group, recognized obesity as a disease in 2013.

☆ FDA advisors reject Biogen's ALS drug for rare and aggressive form of the disease
▼ + stars: | 2023-03-22 | by ( Annika Kim Constantino | ) www.cnbc.com time to read: +3 min

The Food and Drug Administration's independent panel of advisors on Wednesday declined to endorse accelerated approval of Biogen's investigational ALS drug for a rare and aggressive form of the disease. The drug tofersen was developed to treat a rare genetic form of amyotrophic lateral sclerosis, or ALS. That number is even smaller in the U.S., with roughly 330 people affected by the SOD1 mutation. The median survival time from diagnosis with the rare form of ALS to death is 2.7 years, according to the company. The SOD1 mutation is associated with 20% of cases that occur within families.

☆ FDA advisors vote against effectiveness of Biogen's ALS drug for rare and aggressive form of the disease
▼ + stars: | 2023-03-22 | by ( Annika Kim Constantino | ) www.cnbc.com time to read: +3 min

The Food and Drug Administration's independent panel of advisors on Wednesday voted against the effectiveness of Biogen's investigational ALS drug for a rare and aggressive form of the disease. The drug tofersen was developed to treat a rare genetic form of amyotrophic lateral sclerosis, or ALS. That number is even smaller in the U.S., with roughly 330 people affected by the SOD1 mutation. The median survival time from diagnosis with the rare form of ALS to death is 2.7 years, according to the company. The SOD1 mutation is associated with 20% of cases that occur within families.

☆ Jim Boeheim Is Out at Syracuse After 47 Seasons as Basketball Coach
▼ + stars: | 2023-03-09 | by ( Laine Higgins | ) www.wsj.com time to read: 1 min

Jim Boeheim is out at Syracuse after 47 seasons as men’s basketball coach. Shortly after Syracuse’s season ended with a buzzer-beater loss to Wake Forest in the Atlantic Coast Conference tournament on Wednesday, the Orange’s 78-year-old Hall of Fame coach, Jim Boeheim, addressed the topic of his future. “As I’ve said from day one when I started working here, the university hired me, and it’s their choice what they want to do. I always have the choice of retirement, but it’s their decision as to whether I coach or not. It always has been,” Boeheim said.

☆ For women's sports, the media buys are becoming a big deal
▼ + stars: | 2023-03-04 | by ( Kaitlin Balasaygun | ) www.cnbc.com time to read: +3 min

A recent Ally Financial ad buy with Disney 's ESPN focused on women's sports may be the biggest deal yet — in importance as much as the dollars attached. The one-year, multimillion-dollar deal requires 90% of its investment to be put to women's sports, through expanding game highlights, branded content and features across ESPN. "It is rare that brands buy media deals, or buy sponsorship deals, where they are as skewed toward women's sports as this one," she said. The bank is the first-ever title sponsor for both the ACC Women's Basketball Tournament and the ACC Women's Soccer Championship, and will also be the exclusive presenting sponsor for the 2023 ACC Women's Lacrosse Championship. A big money year for women's sports in 2022Ally's deal with Disney follows a successful year for women's sports on the media front, with sponsorship deals growing 20% year-over-year, according to sports and entertainment intelligence platform SponsorUnited.

☆ Billy Packer, legendary voice of college basketball Final Fours, dies at 82
▼ + stars: | 2023-01-27 | by ( The Associated Press | ) www.nbcnews.com time to read: +5 min

CHARLOTTE, N.C. — Billy Packer, an Emmy award-winning college basketball broadcaster who covered 34 Final Fours for NBC and CBS, died Thursday. UCLA beat Kentucky in the title game that year in what was John Wooden’s final game as coach. “So sad to learn of the passing of Billy Packer who had such a passion for college basketball,” Vitale tweeted. May Billy RIP.”College basketball analyst Fran Fraschilla tweeted: “We fell in love (with) college basketball because of you. Your voice will remain in my head forever.”From left, announcers Billy Packer, Dick Enberg, and Al McGuire in 1980.

☆ DoNotPay's CEO says threat of 'jail for 6 months' means plan to debut AI 'robot lawyer' in courtroom is on ice
▼ + stars: | 2023-01-26 | by ( Sindhu Sundar | ) www.businessinsider.com time to read: +3 min

DoNotPay's CEO says he will hold off on deploying an AI 'robot lawyer' in traffic case hearings. Joshua Browder said that he received 'threats' over the plan and feared facing 'jail for 6 months.' The ploy always carried a risk, as states closely regulate who can practice law. But regulators may still be a while away from contemplating a full-fledged AI lawyer in court. "We're seeing some reform in regulations around the unauthorized practice of law, and we're becoming less rigid," said Murphy.

☆ Human Composting Should Be an Option for New Yorkers - The New York Times
▼ + stars: | 2022-12-05 | by ( Caitlin Doughty | ) www.nytimes.com time to read: +12 min

Human composting — or, as it’s sometimes referred to, natural organic reduction — fulfills many people’s desire to nurture the earth after dying. In its place, Ms. Spade founded Recompose, a new for-profit company designed to bring human composting to the public. I have no stake in Recompose or any other human composting company.) Human composting, by Recompose’s reckoning, uses just an eighth of this energy and falls in total price between cremation and conventional burial at around $7,000. Human composting reframes the dead body: not something to be protected from nature and the elements, but something meant to return to them.

☆ Vince Dooley, longtime Georgia football coach, dies at 90
▼ + stars: | 2022-10-29 | by ( The Associated Press | ) www.nbcnews.com time to read: +9 min

ATLANTA — Vince Dooley, the football coach who carried himself like a professor and guided Georgia for a quarter-century of success that included the 1980 national championship, died Friday. “Our family is heartbroken by the death of Coach Dooley. He was one of a kind with an unmatched love for UGA!” current Georgia coach Kirby Smart wrote on Twitter. The field at Sanford Stadium was dedicated in his honor during the 2019 football season. At Georgia, Dooley coached a plethora of standout players — from Bill Stanfill to Scott Woerner to Rodney Hampton.

☆ 'Rogue nurse' charged with murder after patients given lethal doses of insulin at North Carolina hospital, officials say
▼ + stars: | 2022-10-26 | by ( Marlene Lenthang | Marlene Lenthang Is A Breaking News Reporter For Nbc News Digital. | ) www.nbcnews.com time to read: +3 min

A "rogue nurse" in North Carolina has been arrested on murder charges after two patients died after he allegedly administered lethal doses of insulin, state officials announced Tuesday. Hayes allegedly administered a lethal dose of insulin to patient Gwen Crawford on Jan. 5, 2022. The second fatal patient was Vickie Lingerfelt, who was allegedly administered a lethal dose of insulin on Jan. 22, 2022. Hayes was further charged with administrating a near-fatal dose of insulin to a third patient on Dec. 1, 2021, but she survived the dose, according to the district attorney. The district attorney described him as a “rogue nurse,” said there was no evidence Hayes knew the patients before the incidents, and he acted alone.

☆ 2 college friends got a $250,000 'Shark Tank' deal with Mark Cuban for the business they built from their dorm room
▼ + stars: | 2022-10-17 | by ( Tom Huddleston Jr. | ) www.cnbc.com time to read: +2 min

Mark Cuban paid his way through college with a variety of side hustles. Sam Chason and Matt Gronberg are two former Wake Forest University classmates who founded their business, Storage Scholars, in 2017. Now, Storage Scholars is now a full-fledged business that operates at 48 schools across the U.S. Their pitch generated interest from multiple Sharks, but Chason and Gronberg clearly seemed most interested in partnering with Cuban. "I know that college debt is a big thing to you, you've been very outspoken about it," Gronberg told Cuban.

☆ Trump-backed congressional candidate Bo Hines says he 'can't afford' to give up his salary. But federal records show he has no salary.
▼ + stars: | 2022-10-17 | by ( Hanna Kang | ) www.businessinsider.com time to read: +3 min

Bo Hines, a congressional candidate from North Carolina, twice claimed that he and his wife "can't afford to give up a month's salary." A trust fund is the only reported asset in Hines' financial disclosure. In the disclosure, Hines reported no salary and no spousal assets, and asserted that he has not excluded any assets that belong to his wife, Mary Charles Hines. Axios' Lachlan Markay first noted Hines' financial situation, which includes no reported bank account or earned income and compensation, and zero loans or liabilities. His trust fund, named Hines Children's Trust, is the only reported asset on his personal financial disclosure.

There has been evidence that the omicron variant tends not to burrow deeply into the lungs as much as previous variants. How quickly do omicron symptoms appear? What is the duration of omicron symptoms? Although much about the omicron variant remains unknown, some experts say it could lead to long Covid, even with mild cases. The BA.5 omicron subvariant accounted for nearly 80% of new Covid cases as of Oct. 8, according to the CDC.

Share this -Link copiedFloridians are livestreaming Hurricane Ian on TikTok Floridians are giving TikTok users a front-row seat to Hurricane Ian. Storm surge map, they didn’t have a color for 12 to 15 feet," he said about the historic levels of storm surge expected near where Ian is expected to make landfall. Share this -Link copiedA view of Hurricane Ian from the International Space Station A view of Hurricane Ian from the International Space Station, on Monday. Share this -Link copiedSatellite images show Hurricane Ian approaching Florida Hurricane Ian over the Gulf of Mexico early Wednesday. Share this -Link copiedIan expected to strengthen until making landfall, officials say Hurricane Ian is still forecast to strengthen until the hurricane makes landfall in Florida, the National Hurricane Center said.

Storm surge map, they didn’t have a color for 12 to 15 feet," he said about the historic levels of storm surge expected near where Ian is expected to make landfall. Share this -Link copiedA view of Hurricane Ian from the International Space Station A view of Hurricane Ian from the International Space Station, on Monday. “We are extremely concerned about the potential impacts Hurricane Ian may have on phosphate facilities around the state,” Whitlock added. Share this -Link copiedIan strengthens into Category 4 storm Hurricane Ian has strengthened into a Category 4 storm as it advances upon Florida's west coast. Share this -Link copiedSatellite images show Hurricane Ian approaching Florida Hurricane Ian over the Gulf of Mexico early Wednesday.

Share this -Link copiedView of Hurricane Ian from International Space Station View of Hurricane Ian from the International Space Station. Share this -Link copiedIan on track to make landfall in Florida as 'catastrophic' Category 4 storm Hurricane Ian is strengthening as it nears Florida's west coast, officials said. “We are extremely concerned about the potential impacts Hurricane Ian may have on phosphate facilities around the state,” Whitlock added. Share this -Link copiedIan strengthens into Category 4 storm Hurricane Ian has strengthened into a Category 4 storm as it advances upon Florida's west coast. Share this -Link copiedSatellite images show Hurricane Ian approaching Florida Hurricane Ian over the Gulf of Mexico early on Wednesday morning.

☆ These maps show which parts of the US are already having a green energy jobs boom
▼ + stars: | 2022-09-23 | by ( Madison Hoff | ) www.businessinsider.com time to read: +7 min

With the Inflation Reduction Act signed into law, there could be more postings for green energy jobs. Curtis pointed out that many of the green job postings fall in "red" areas of the US, such as in parts of Texas. "Future environmental legislation is more likely to pass if the green energy transition is perceived as helping these regions." Curtis told Insider one takeaway of his and his co-author's research is just how large growth in these green energy jobs has been since 2007. And more clean or green energy jobs could be made as a result of the Inflation Reduction Act.

☆ How to get rid of razor burn, bumps and ingrown hair
▼ + stars: | 2022-09-21 | by ( Zoe Malin | Zoe Malin Is The Associate Updates Editor For Select On Nbc News. | ) www.nbcnews.com time to read: +10 min

Razor burn and ingrown hairs are uncomfortable and unsightly, but thankfully, avoidable. So if you suffer from razor burn or bumps, or want to avoid them in the future, consider these expert tips from dermatologists. SKIP AHEAD: How to prevent razor burn | What are ingrown hairs and how to prevent themWhat is razor burn and how do you treat it? (Note that razor burn is different from razor bumps, or ingrown hairs, which we cover below). In fact, King said the worst marks come from picking at ingrown hairs, not the ingrown hairs themselves.

As yet another Alzheimer's drug targeting plaque buildup in the brain fails to improve cognition in patients, leading scientists said a significant shift is underway in the search for effective treatments for the disease. By 2050, that number is projected to rise to nearly 13 million, according to an estimate from the Alzheimer’s Association. Alzheimer’s disease is often referred to as “Type 3 diabetes,” a brain-specific form of diabetes that is the result of the brain’s neurons lacking glucose, said John Didsbury, the CEO of T3D Therapeutics. Data from the longest-ever phase 3 trial of exercise on cognition released at the conference on Tuesday found that exercise may stall cognitive decline in Alzheimer’s patients. He said it’s only a matter of time before we see more research discoveries that show potential for slowing Alzheimer’s disease, possibly within the next year or two.

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